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Comparison of neuroendocrine tumor detection and characterization using DOTATOC-PET in correlation with contrast enhanced CT and delayed contrast enhanced MRI.

Identifieur interne : 000F38 ( Main/Exploration ); précédent : 000F37; suivant : 000F39

Comparison of neuroendocrine tumor detection and characterization using DOTATOC-PET in correlation with contrast enhanced CT and delayed contrast enhanced MRI.

Auteurs : RBID : pubmed:22236704

English descriptors

Abstract

We evaluated the rate of successful characterization of gastroenteropancreatic neuroendocrine tumors (NETs) present with an increased somatostatin receptor, comparing CE-CT with CE-MRI, each in correlation with DOTATOC-PET.

DOI: 10.1016/j.ejrad.2011.11.007
PubMed: 22236704

Links toward previous steps (curation, corpus...)


Le document en format XML

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<title xml:lang="en">Comparison of neuroendocrine tumor detection and characterization using DOTATOC-PET in correlation with contrast enhanced CT and delayed contrast enhanced MRI.</title>
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<name sortKey="Giesel, F L" uniqKey="Giesel F">F L Giesel</name>
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<nlm:affiliation>Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany. f.giesel@dkfz.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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<name sortKey="Kratochwil, C" uniqKey="Kratochwil C">C Kratochwil</name>
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<name sortKey="Mehndiratta, A" uniqKey="Mehndiratta A">A Mehndiratta</name>
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<name sortKey="Wulfert, S" uniqKey="Wulfert S">S Wulfert</name>
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<name sortKey="Moltz, J H" uniqKey="Moltz J">J H Moltz</name>
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<name sortKey="Zechmann, C M" uniqKey="Zechmann C">C M Zechmann</name>
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<name sortKey="Kauczor, H U" uniqKey="Kauczor H">H U Kauczor</name>
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<name sortKey="Haberkorn, U" uniqKey="Haberkorn U">U Haberkorn</name>
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<name sortKey="Ley, S" uniqKey="Ley S">S Ley</name>
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<term>Neuroendocrine Tumors (diagnosis)</term>
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<term>Female</term>
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<div type="abstract" xml:lang="en">We evaluated the rate of successful characterization of gastroenteropancreatic neuroendocrine tumors (NETs) present with an increased somatostatin receptor, comparing CE-CT with CE-MRI, each in correlation with DOTATOC-PET.</div>
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<DateCreated>
<Year>2012</Year>
<Month>08</Month>
<Day>20</Day>
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<DateCompleted>
<Year>2013</Year>
<Month>01</Month>
<Day>24</Day>
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<DateRevised>
<Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
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<ISSN IssnType="Electronic">1872-7727</ISSN>
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<Volume>81</Volume>
<Issue>10</Issue>
<PubDate>
<Year>2012</Year>
<Month>Oct</Month>
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</JournalIssue>
<Title>European journal of radiology</Title>
<ISOAbbreviation>Eur J Radiol</ISOAbbreviation>
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<ArticleTitle>Comparison of neuroendocrine tumor detection and characterization using DOTATOC-PET in correlation with contrast enhanced CT and delayed contrast enhanced MRI.</ArticleTitle>
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<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">We evaluated the rate of successful characterization of gastroenteropancreatic neuroendocrine tumors (NETs) present with an increased somatostatin receptor, comparing CE-CT with CE-MRI, each in correlation with DOTATOC-PET.</AbstractText>
<AbstractText Label="METHODS AND MATERIALS" NlmCategory="METHODS">8 patients with GEP-NET were imaged using CE-MRI (Gd-EOB-DTPA), CE-CT (Imeron 400) and DOTATOC-PET. Contrast-enhancement of normal liver-tissue and metastasis was quantified with ROI-technique. Tumor delineation was assessed with visual-score in blind-read-analysis by two experienced radiologists.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Out of 40 liver metastases in patients with NETs, all were detected by CE-MRI and the lesion extent could be adequately assessed, whereas CT failed to detect 20% of all metastases. The blind-read-score of CT in arterial and portal phase was median -0.65 and -1.4, respectively, and 2.7 for delayed-MRI. The quantitative ROI-analysis presented an improved contrast-enhancement-ratio with a median of 1.2, 1.6 and 3.3 for CE-CT arterial, portal-phase and delayed-MRI respectively.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Late CE-MRI was superior to CE-CT in providing additionally morphologic characterization and exact lesion extension of hepatic metastases from neuroendocrine tumor detected with DOTATOC-PET. Therefore, late enhanced Gd-EOB-DTPA-MRI seems to be the adequate imaging modality for combination with DOTATOC-PET to provide complementary (macroscopic and molecular) tumor characterization in hepatic metastasized NETs.</AbstractText>
<CopyrightInformation>Copyright © 2011. Published by Elsevier Ireland Ltd.</CopyrightInformation>
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<Language>eng</Language>
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